Vitamin B Dementia

Unraveling the mystery behind the aging brain has been one of the most heavily studied topics in the scientific community. One of the more recent studies conducted by a team of scientists at the University of Oxford in the UK, may have found a link between vitamin B and the prevention of, or slowing down the progression of age-related memory loss. The Oxford Project investigated memory and aging in a group of 168 participants, aged over 70, who suffered from mild cognitive impairment (MCI). The study, co-funded by the Alzheimer's Research Trust, found that administration of B vitamins may help delay the onset of mental decline in the elderly.

A Link Between Vitamin B and Brain Atrophy

Mild cognitive impairment is typically indicative of brain atrophy, a normal process of aging. According to a study published in The Lancet, more than 50 percent of MCI patients over age 65 progress toward dementia within 5 years.2 The Oxford Project studied the vitamin B dementia theory by administering high doses of Vitamin B6, Vitamin B12 and folic acid to 85 participants, and a placebo to 83. At the end of two years, scientists measured brain atrophy in both control groups. The average brain reduction was 1.08 percent per year in the group that took the placebo and 0.76 percent per year in the group that was given B vitamins. The results showed that Vitamin B intake slowed brain atrophy by an overwhelming 30 percent.

Vitamin B administration to patients with dementia helped to lower levels of an amino acid in the blood called homocysteine. Scientists noted that those who had the highest levels of homocysteine in the blood at the beginning of the trial showed the most benefits from taking large doses of Vitamin B, showing up to a 50 percent reduction in brain shrinkage when compared to their counterparts who were given a placebo.

The Oxford Project is a break-through in medical research and a stimulus for further study on modifiable nutritional factors that may help decelerate the atrophy of the brain, thus delaying cognitive decline. Dr. David Smith, a co-leader of the study, said: “It is our hope that this simple and safe treatment will delay development of Alzheimers in many people who suffer from mild memory problems.” These findings are corroborated by thirty years of Vitamin B-brain studies, highlighting the importance of Vitamin B nutrition, particularly in people over age 65, for optimal brain functions. Vitamin B deficiency in the elderly has been linked to deterioration of brain function and dementia.

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1. 1.Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial, Public Library of Science ONE [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0012244]
2. 2.Mild Cognitive Impairment, The Lancet, Volume 367, Issue 9518, Pages 1262 - 1270, 15 April 2006.